The role of partial nephrectomy for the management of sporadic renal angiomyolipoma.

Journal Article (Journal Article)

OBJECTIVES: Angiomyolipoma is a benign renal tumor that has a propensity to grow over time and may cause local complications. Given the benign nature of these lesions, renal-preserving treatments are favored. We evaluated our experience with nephron-sparing surgery for renal angiomyolipoma. METHODS: We reviewed our institutional nephrectomy registry to identify patients treated with nephron-sparing surgery for renal angiomyolipoma between 1970 and 2004. Patients with a diagnosis of tuberous sclerosis were excluded. Patient demographics, perioperative complications, and postoperative outcomes were recorded. RESULTS: We identified 58 patients treated with nephron-sparing surgery for sporadic renal angiomyolipoma, including 44 women and 14 men. The median tumor size was 3.9 cm (range, 0.8-12.5 cm). In 7 patients (12%), several ipsilateral angiomyolipomas were resected, whereas 2 patients were treated with nephron-sparing surgery for bilateral angiomyolipomas. The overall early complication rate was 12%, including a urine leak in 3 (5%) patients. At a median postoperative follow-up of 8 years (range, 1-31 years), 2 (3.4%) patients had radiographic evidence of local recurrence, although no patient experienced symptom recurrence. The median preoperative serum creatinine level was 1.0 mg/dL (range, 0.5-3.9 mg/dL), and the median creatinine level at last follow-up was 1.1 mg/dL (range, 0.6-3.6 mg/dL). No patient developed de novo chronic renal insufficiency after nephron-sparing surgery, including 4 patients treated for angiomyolipomas in a solitary kidney. CONCLUSIONS: Nephron-sparing surgery for sporadic renal angiomyolipomas offers preservation of renal function and is associated with acceptable complication and low local recurrence rates. The results of this study support nephron-sparing surgery for these lesions.

Full Text

Duke Authors

Cited Authors

  • Boorjian, SA; Frank, I; Inman, B; Lohse, CM; Cheville, JC; Leibovich, BC; Blute, ML

Published Date

  • December 2007

Published In

Volume / Issue

  • 70 / 6

Start / End Page

  • 1064 - 1068

PubMed ID

  • 18158015

Electronic International Standard Serial Number (EISSN)

  • 1527-9995

Digital Object Identifier (DOI)

  • 10.1016/j.urology.2007.07.045


  • eng

Conference Location

  • United States