Short-term effects of formaldehyde on peak expiratory flow and irritant symptoms.

Journal Article

The authors studied the respiratory effects of formaldehyde exposure among students who dissected cadavers in a gross anatomy laboratory. Peak expiratory flow and respiratory symptoms were measured before and after each weekly laboratory session. Each of 38 students was exposed to formaldehyde for 2.5 hr/wk for 14 wk. Individual, daily formaldehyde measurements averaged 1.1 ppm (standard deviation = 0.56 ppm). Multivariate models demonstrated two different time scales of effect of formaldehyde on peak expiratory flow: (1) exposure during the previous 2.5 hr reduced peak expiratory flow by -1.0% per ppm, and (2) average exposure during all preceding weeks reduced peak expiratory flow by an additional -0.5% per ppm of formaldehyde. However, the short-term exposure effect was diminished during the first 4 wk, suggesting at least partial acclimatization. Symptom reporting was also associated with exposure during the previous 2.5 hr, and similar evidence of acclimatization was observed. These results suggest that there are two different time scales of response to formaldehyde, and they emphasize the need for longitudinal studies, characterized by quantitative exposure characterization, and frequent measurements of outcome.

Full Text

Duke Authors

Cited Authors

  • Kriebel, D; Myers, D; Cheng, M; Woskie, S; Cocanour, B

Published Date

  • January 2001

Published In

Volume / Issue

  • 56 / 1

Start / End Page

  • 11 - 18

PubMed ID

  • 11256851

International Standard Serial Number (ISSN)

  • 0003-9896

Digital Object Identifier (DOI)

  • 10.1080/00039890109604049

Language

  • eng

Conference Location

  • United States