Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.


Journal Article

In this article, we have characterized and compared gene expression profiles from laser capture microdissected neurons in six functionally and anatomically distinct regions from clinically and histopathologically normal aged human brains. These regions, which are also known to be differentially vulnerable to the histopathological and metabolic features of Alzheimer's disease (AD), include the entorhinal cortex and hippocampus (limbic and paralimbic areas vulnerable to early neurofibrillary tangle pathology in AD), posterior cingulate cortex (a paralimbic area vulnerable to early metabolic abnormalities in AD), temporal and prefrontal cortex (unimodal and heteromodal sensory association areas vulnerable to early neuritic plaque pathology in AD), and primary visual cortex (a primary sensory area relatively spared in early AD). These neuronal profiles will provide valuable reference information for future studies of the brain, in normal aging, AD and other neurological and psychiatric disorders.

Full Text

Cited Authors

  • Liang, WS; Dunckley, T; Beach, TG; Grover, A; Mastroeni, D; Walker, DG; Caselli, RJ; Kukull, WA; McKeel, D; Morris, JC; Hulette, C; Schmechel, D; Alexander, GE; Reiman, EM; Rogers, J; Stephan, DA

Published Date

  • February 12, 2007

Published In

Volume / Issue

  • 28 / 3

Start / End Page

  • 311 - 322

PubMed ID

  • 17077275

Pubmed Central ID

  • 17077275

Electronic International Standard Serial Number (EISSN)

  • 1531-2267

Digital Object Identifier (DOI)

  • 10.1152/physiolgenomics.00208.2006


  • eng

Conference Location

  • United States