Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain.
Published
Journal Article
In this article, we have characterized and compared gene expression profiles from laser capture microdissected neurons in six functionally and anatomically distinct regions from clinically and histopathologically normal aged human brains. These regions, which are also known to be differentially vulnerable to the histopathological and metabolic features of Alzheimer's disease (AD), include the entorhinal cortex and hippocampus (limbic and paralimbic areas vulnerable to early neurofibrillary tangle pathology in AD), posterior cingulate cortex (a paralimbic area vulnerable to early metabolic abnormalities in AD), temporal and prefrontal cortex (unimodal and heteromodal sensory association areas vulnerable to early neuritic plaque pathology in AD), and primary visual cortex (a primary sensory area relatively spared in early AD). These neuronal profiles will provide valuable reference information for future studies of the brain, in normal aging, AD and other neurological and psychiatric disorders.
Full Text
Cited Authors
- Liang, WS; Dunckley, T; Beach, TG; Grover, A; Mastroeni, D; Walker, DG; Caselli, RJ; Kukull, WA; McKeel, D; Morris, JC; Hulette, C; Schmechel, D; Alexander, GE; Reiman, EM; Rogers, J; Stephan, DA
Published Date
- February 12, 2007
Published In
Volume / Issue
- 28 / 3
Start / End Page
- 311 - 322
PubMed ID
- 17077275
Pubmed Central ID
- 17077275
Electronic International Standard Serial Number (EISSN)
- 1531-2267
Digital Object Identifier (DOI)
- 10.1152/physiolgenomics.00208.2006
Language
- eng
Conference Location
- United States