A randomized trial of atropine regimens for treatment of moderate amblyopia in children.


Journal Article

OBJECTIVE:To compare daily atropine to weekend atropine as prescribed treatments for moderate amblyopia in children younger than 7 years. DESIGN:Prospective, randomized multicenter clinical trial (30 sites). PARTICIPANTS:One hundred sixty-eight children younger than 7 years with amblyopia in the range of 20/40 to 20/80 associated with strabismus, anisometropia, or both. INTERVENTION:Randomization either to daily atropine or to weekend atropine for 4 months. Partial responders were continued on the randomized treatment until no further improvement was noted. MAIN OUTCOME MEASURE:Visual acuity (VA) in the amblyopic eye after 4 months. RESULTS:The improvement in VA of the amblyopic eye from baseline to 4 months averaged 2.3 lines in each group. The VA of the amblyopic eye at study completion was either (1) at least 20/25 or (2) better than or equal to that of the sound eye in 39 children (47%) in the daily group and 45 children (53%) in the weekend group. The VA of the sound eye at the end of follow-up was reduced by 2 lines in one patient in each group. Stereoacuity outcomes were similar in the 2 groups. CONCLUSIONS:Weekend atropine provides an improvement in VA of a magnitude similar to that of the improvement provided by daily atropine in treating moderate amblyopia in children 3 to 7 years old. This article contains additional online-only material available at http://www.ophsource.com/periodicals/ophtha.

Full Text

Cited Authors

  • Repka, MX; Cotter, SA; Beck, RW; Kraker, RT; Birch, EE; Everett, DF; Hertle, RW; Holmes, JM; Quinn, GE; Sala, NA; Scheiman, MM; Stager, DR; Wallace, DK; Pediatric Eye Disease Investigator Group,

Published Date

  • November 2004

Published In

Volume / Issue

  • 111 / 11

Start / End Page

  • 2076 - 2085

PubMed ID

  • 15522375

Pubmed Central ID

  • 15522375

Electronic International Standard Serial Number (EISSN)

  • 1549-4713

International Standard Serial Number (ISSN)

  • 0161-6420

Digital Object Identifier (DOI)

  • 10.1016/j.ophtha.2004.04.032


  • eng