A randomized trial of prescribed patching regimens for treatment of severe amblyopia in children.


Journal Article

OBJECTIVE:To compare full-time patching (all hours or all but 1 hour per day) to 6 hours of patching per day, as prescribed treatments for severe amblyopia in children younger than 7 years. DESIGN:Prospective, randomized multicenter clinical trial (32 sites). PARTICIPANTS:One hundred seventy-five children younger than 7 years with amblyopia in the range of 20/100 to 20/400. INTERVENTION:Randomization either to full-time patching or to 6 hours of patching per day, each combined with at least 1 hour of near-visual activities during patching. MAIN OUTCOME MEASURE:Visual acuity in the amblyopic eye after 4 months. RESULTS:Visual acuity in the amblyopic eye improved a similar amount in both groups. The improvement in the amblyopic eye acuity from baseline to 4 months averaged 4.8 lines in the 6-hour group and 4.7 lines in the full-time group (P = 0.45). CONCLUSION:Six hours of prescribed daily patching produces an improvement in visual acuity that is of similar magnitude to the improvement produced by prescribed full-time patching in treating severe amblyopia in children 3 to less than 7 years of age.

Full Text

Cited Authors

  • Holmes, JM; Kraker, RT; Beck, RW; Birch, EE; Cotter, SA; Everett, DF; Hertle, RW; Quinn, GE; Repka, MX; Scheiman, MM; Wallace, DK; Pediatric Eye Disease Investigator Group,

Published Date

  • November 2003

Published In

Volume / Issue

  • 110 / 11

Start / End Page

  • 2075 - 2087

PubMed ID

  • 14597512

Pubmed Central ID

  • 14597512

Electronic International Standard Serial Number (EISSN)

  • 1549-4713

International Standard Serial Number (ISSN)

  • 0161-6420

Digital Object Identifier (DOI)

  • 10.1016/j.ophtha.2003.08.001


  • eng