New roles for pyruvate kinase M2: working out the Warburg effect.


Journal Article

The origins and role of the Warburg effect have remained uncertain for many years. Two recent studies demonstrate that an embryonic- and cancer-cell-specific isoform of the enzyme pyruvate kinase M2 (PKM2) is regulated by binding to phospho-tyrosine motifs and promotes increased cell growth and tumor development. PKM2 enhances the use of glycolytic intermediates for macromolecular biosynthesis and tumor growth. These findings illustrate the distinct advantages of this metabolic phenotype in cancer cell growth.

Full Text

Duke Authors

Cited Authors

  • Ferguson, EC; Rathmell, JC

Published Date

  • August 2008

Published In

Volume / Issue

  • 33 / 8

Start / End Page

  • 359 - 362

PubMed ID

  • 18603432

Pubmed Central ID

  • 18603432

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/j.tibs.2008.05.006


  • eng

Conference Location

  • England