Cervical screening and general physical examination behaviors of women exposed in utero to diethylstilbestrol.

Journal Article (Journal Article;Multicenter Study)

OBJECTIVE: To estimate whether women exposed in utero to diethylstilbestrol (DES) report receiving more cervical and general physical examinations compared to unexposed women. MATERIALS AND METHODS: 1994 Diethylstilbestrol Adenosis cohort data are used to assess the degree of recommended compliance of cervical screenings found in 3,140 DES-exposed and 826 unexposed women. Participants were enrolled at 4 sites: Houston, Boston, Rochester, and Los Angeles. Logistic regression modeling was used to analyze mailed questionnaire data, which included reported frequency over the preceding 5 years (1990-1994) of Papanicolaou smears and general physical examinations. RESULTS: Diethylstilbestrol-exposed women exceeded the recommended frequency of Papanicolaou smear screenings [adjusted odds ratio (aOR) = 2.15, 95% CI (confidence interval) = 1.60-2.88] compared to the unexposed. This association held among those without a history of cervical intraepithelial neoplasia (aOR = 1.88, 95% CI = 1.35-2.62). Diethylstilbestrol-exposed women exceeded annual recommendations for physical examinations (aOR = 2.27, 95% CI = 1.16-4.43) among women without a history of chronic disease when compared to unexposed women. CONCLUSIONS: Most DES-exposed women are receiving cervical cancer screening at least at recommended intervals, but one third of the women are not receiving annual Papanicolaou smear examinations.

Full Text

Duke Authors

Cited Authors

  • Camp, EA; Coker, AL; Troisi, R; Robboy, SJ; Noller, KL; Goodman, KJ; Titus-Ernstoff, LT; Hatch, EE; Herbst, AL; Kaufman, RH; Adam, E

Published Date

  • April 2008

Published In

Volume / Issue

  • 12 / 2

Start / End Page

  • 111 - 117

PubMed ID

  • 18369304

Electronic International Standard Serial Number (EISSN)

  • 1526-0976

Digital Object Identifier (DOI)

  • 10.1097/LGT.0b013e31815ae980


  • eng

Conference Location

  • United States