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Laryngeal transplantation in the setting of cancer: a rat model.

Publication ,  Journal Article
Shipchandler, TZ; Lorenz, RR; Lee, WT; Teker, AM; Dan, O; Strome, M
Published in: Laryngoscope
December 2008

OBJECTIVE: Traditional immunosuppressive regimens make laryngeal transplantation in cancer patients prohibitive because of the increased risk of recurrence. Everolimus, a recently developed immunosuppressant, has demonstrated significant antitumor properties. The purpose of this study was to examine the effects of everolimus alone and in combination with other immunosuppressants on tumor growth in a combined laryngeal transplantation and tumor model. STUDY DESIGN: Animal, prospective, randomized, controlled, and blinded. METHODS: One million squamous cell carcinoma cells (SCC-158) were injected intravenously into a total of 40 rats 1 day before laryngeal transplantation. Rats were divided into four groups differing by immunosuppressive regimens. Lung surface metastases were counted 21 days after inoculation, and numerical transplantation rejection scores were recorded. A separate experiment for comparison was performed with no transplant on 24 rats, but with the same immunosuppressive treatment groups. RESULTS: The median number of lung surface metastases were: a) control (i.e., no immunosuppression): 85; b) everolimus 1.0 mg/kg: 25; c) tacrolimus 1.2 mg/kg: 1650; d) everolimus 1.0 mg/kg + tacrolimus 0.05 mg/kg: 1300. Rats receiving everolimus alone showed a statistically significant decrease in pulmonary surface metastases compared with the other groups. Transplanted rats had no difference in their outcomes when compared with non-transplanted rats. CONCLUSION: Everolimus significantly decreases SCC-158 growth in our combined transplantation and tumor model compared with controls and other immunosuppressants.

Duke Scholars

Published In

Laryngoscope

DOI

EISSN

1531-4995

Publication Date

December 2008

Volume

118

Issue

12

Start / End Page

2166 / 2171

Location

United States

Related Subject Headings

  • Tacrolimus
  • Sirolimus
  • Rats, Inbred F344
  • Rats
  • Otorhinolaryngology
  • Neoplasm Transplantation
  • Neoplasm Recurrence, Local
  • Male
  • Lung Neoplasms
  • Larynx
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shipchandler, T. Z., Lorenz, R. R., Lee, W. T., Teker, A. M., Dan, O., & Strome, M. (2008). Laryngeal transplantation in the setting of cancer: a rat model. Laryngoscope, 118(12), 2166–2171. https://doi.org/10.1097/MLG.0b013e3181855108
Shipchandler, Taha Z., Robert R. Lorenz, Walter T. Lee, Aysenur Meric Teker, Olivia Dan, and Marshall Strome. “Laryngeal transplantation in the setting of cancer: a rat model.Laryngoscope 118, no. 12 (December 2008): 2166–71. https://doi.org/10.1097/MLG.0b013e3181855108.
Shipchandler TZ, Lorenz RR, Lee WT, Teker AM, Dan O, Strome M. Laryngeal transplantation in the setting of cancer: a rat model. Laryngoscope. 2008 Dec;118(12):2166–71.
Shipchandler, Taha Z., et al. “Laryngeal transplantation in the setting of cancer: a rat model.Laryngoscope, vol. 118, no. 12, Dec. 2008, pp. 2166–71. Pubmed, doi:10.1097/MLG.0b013e3181855108.
Shipchandler TZ, Lorenz RR, Lee WT, Teker AM, Dan O, Strome M. Laryngeal transplantation in the setting of cancer: a rat model. Laryngoscope. 2008 Dec;118(12):2166–2171.
Journal cover image

Published In

Laryngoscope

DOI

EISSN

1531-4995

Publication Date

December 2008

Volume

118

Issue

12

Start / End Page

2166 / 2171

Location

United States

Related Subject Headings

  • Tacrolimus
  • Sirolimus
  • Rats, Inbred F344
  • Rats
  • Otorhinolaryngology
  • Neoplasm Transplantation
  • Neoplasm Recurrence, Local
  • Male
  • Lung Neoplasms
  • Larynx