Understanding specificity and sensitivity of T-cell recognition.

Journal Article (Review)

The response of T cells to antigen shows an amazing degree of both sensitivity and specificity, with a cell responding to 1-10 peptide-MHC complexes and being sensitive to single amino acid substitutions. Kinetic proofreading or feedback pathways achieve specificity at the level of the receptor, whereas serial engagement of receptors by ligand molecules enhances sensitivity. Crosstalk between receptors, integration of signals and/or tuning of responses is important at the level of the cell. Induction of anergic or regulatory cells by suboptimal stimuli prevents cell activation by multiple encounters with weak ligands. Thus, for optimal sensitivity and specificity, it is necessary to have mechanisms that operate at the level of the receptor, the cell and finally, the population of responding cells.

Full Text

Duke Authors

Cited Authors

  • George, AJT; Stark, J; Chan, C

Published Date

  • December 2005

Published In

Volume / Issue

  • 26 / 12

Start / End Page

  • 653 - 659

PubMed ID

  • 16236548

International Standard Serial Number (ISSN)

  • 1471-4906

Digital Object Identifier (DOI)

  • 10.1016/j.it.2005.09.011

Language

  • eng

Conference Location

  • England