Association mapping via a class of haplotype-sharing statistics.

Journal Article (Journal Article)

We present a class of haplotype-sharing statistics useful for association mapping in case-parent trio data. The framework presented allows derivation of novel tests as well as new simplified variance estimators for previously proposed tests. We give an overview of this framework and apply four such tests to the simulated data of Genetic Analysis Workshop 15. We find that these haplotype-based statistics result in greater power and better risk locus localization than the single locus single-nucleotide polymorphism analysis.

Full Text

Duke Authors

Cited Authors

  • Allen, AS; Satten, GA

Published Date

  • 2007

Published In

Volume / Issue

  • 1 Suppl 1 /

Start / End Page

  • S123 -

PubMed ID

  • 18466465

Pubmed Central ID

  • PMC2367563

Electronic International Standard Serial Number (EISSN)

  • 1753-6561

Digital Object Identifier (DOI)

  • 10.1186/1753-6561-1-s1-s123


  • eng

Conference Location

  • England