A phosphatase controls the fate of receptor-regulated Smads.
In this issue of Cell, Lin et al. (2006) answer one of the long-standing questions in the TGFbeta field by identifying a phosphatase, PPM1A, that directly dephosphorylates Smad2 and Smad3 to limit their activation.
Schilling, SH; Datto, MB; Wang, X-F
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