Neuroimaging correlates of dementia rating scale performance at baseline and 12-month follow-up among patients with vascular dementia.

Journal Article (Clinical Trial;Journal Article)

The authors previously reported that subcortical hyperintensity (SH) and whole-brain volume (WBV) each covary with different subscale scores of the Mattis Dementia Rating Scale (MDRS) among vascular dementia (VaD) patients. The present longitudinal analysis examined these relationships for change. The authors found that SH volume increased and WBV decreased significantly over 12 months. At baseline, SH volume accounted for significant variance in MDRS total score and every subscale score, except Memory. WBV was unrelated to any MDRS measure. After 12 months, SH volume was related only to the Construction subscale score, whereas WBV accounted for the majority of variance in Attention and Memory subscale performance. These findings indicate that although SH volume increases with disease progression, the relative impact of SH volume on cognitive status decreases among patients with advanced VaD.

Full Text

Duke Authors

Cited Authors

  • Sweet, LH; Paul, RH; Cohen, RA; Moser, D; Ott, BR; Gordon, N; Browndyke, JN; Shah, P; Garrett, KD

Published Date

  • December 2003

Published In

Volume / Issue

  • 16 / 4

Start / End Page

  • 240 - 244

PubMed ID

  • 14653434

International Standard Serial Number (ISSN)

  • 0891-9887

Digital Object Identifier (DOI)

  • 10.1177/0891988703258322


  • eng

Conference Location

  • United States