From genotype to phenotype: systems biology meets natural variation.

Journal Article (Journal Article)

The promise that came with genome sequencing was that we would soon know what genes do, particularly genes involved in human diseases and those of importance to agriculture. We now have the full genomic sequence of human, chimpanzee, mouse, chicken, dog, worm, fly, rice, and cress, as well as those for a wide variety of other species, and yet we still have a lot of trouble figuring out what genes do. Mapping genes to their function is called the "genotype-to-phenotype problem," where phenotype is whatever is changed in the organism when a gene's function is altered.

Full Text

Duke Authors

Cited Authors

  • Benfey, PN; Mitchell-Olds, T

Published Date

  • April 2008

Published In

Volume / Issue

  • 320 / 5875

Start / End Page

  • 495 - 497

PubMed ID

  • 18436781

Pubmed Central ID

  • PMC2727942

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1153716


  • eng