From genotype to phenotype: systems biology meets natural variation.
Journal Article (Journal Article)
The promise that came with genome sequencing was that we would soon know what genes do, particularly genes involved in human diseases and those of importance to agriculture. We now have the full genomic sequence of human, chimpanzee, mouse, chicken, dog, worm, fly, rice, and cress, as well as those for a wide variety of other species, and yet we still have a lot of trouble figuring out what genes do. Mapping genes to their function is called the "genotype-to-phenotype problem," where phenotype is whatever is changed in the organism when a gene's function is altered.
Full Text
Duke Authors
Cited Authors
- Benfey, PN; Mitchell-Olds, T
Published Date
- April 2008
Published In
Volume / Issue
- 320 / 5875
Start / End Page
- 495 - 497
PubMed ID
- 18436781
Pubmed Central ID
- PMC2727942
Electronic International Standard Serial Number (EISSN)
- 1095-9203
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.1153716
Language
- eng