Primary cerebral ALK-1-positive anaplastic large cell lymphoma in a child. Case report and literature review.

Published

Journal Article (Review)

A 4-year-old African American male was referred to the Pediatric Neurosurgery Service for evaluation of new onset seizures and worsening mental status. An MRI of the brain revealed a pineal region mass with diffuse leptomeningeal enhancement and compression of the basilar cisterns. A biopsy of the brain revealed histologic and immunophenotypic findings characteristic of ALK-1+ anaplastic large cell lymphoma (ALCL). ALCL rarely occurs in the central nervous system and poses a significant diagnostic challenge often leading to a delay in the initiation of appropriate treatment. We describe a case of a rapidly deteriorating clinical course in a child with central nervous system ALCL and review the current literature on ALCL occurring in the central nervous system.

Full Text

Duke Authors

Cited Authors

  • Karikari, IO; Thomas, KK; Lagoo, A; Cummings, TJ; George, TM

Published Date

  • 2007

Published In

Volume / Issue

  • 43 / 6

Start / End Page

  • 516 - 521

PubMed ID

  • 17992044

Pubmed Central ID

  • 17992044

Electronic International Standard Serial Number (EISSN)

  • 1423-0305

Digital Object Identifier (DOI)

  • 10.1159/000108799

Language

  • eng

Conference Location

  • Switzerland