Primary cerebral ALK-1-positive anaplastic large cell lymphoma in a child. Case report and literature review.
A 4-year-old African American male was referred to the Pediatric Neurosurgery Service for evaluation of new onset seizures and worsening mental status. An MRI of the brain revealed a pineal region mass with diffuse leptomeningeal enhancement and compression of the basilar cisterns. A biopsy of the brain revealed histologic and immunophenotypic findings characteristic of ALK-1+ anaplastic large cell lymphoma (ALCL). ALCL rarely occurs in the central nervous system and poses a significant diagnostic challenge often leading to a delay in the initiation of appropriate treatment. We describe a case of a rapidly deteriorating clinical course in a child with central nervous system ALCL and review the current literature on ALCL occurring in the central nervous system.
Duke Scholars
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Related Subject Headings
- Neurology & Neurosurgery
- Male
- Lymphoma, Large-Cell, Anaplastic
- Humans
- Child, Preschool
- Brain Neoplasms
- Biomarkers, Tumor
- Activin Receptors, Type II
- 3213 Paediatrics
- 3209 Neurosciences
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Neurology & Neurosurgery
- Male
- Lymphoma, Large-Cell, Anaplastic
- Humans
- Child, Preschool
- Brain Neoplasms
- Biomarkers, Tumor
- Activin Receptors, Type II
- 3213 Paediatrics
- 3209 Neurosciences