Primary cerebral ALK-1-positive anaplastic large cell lymphoma in a child. Case report and literature review.
Journal Article (Journal Article;Review)
A 4-year-old African American male was referred to the Pediatric Neurosurgery Service for evaluation of new onset seizures and worsening mental status. An MRI of the brain revealed a pineal region mass with diffuse leptomeningeal enhancement and compression of the basilar cisterns. A biopsy of the brain revealed histologic and immunophenotypic findings characteristic of ALK-1+ anaplastic large cell lymphoma (ALCL). ALCL rarely occurs in the central nervous system and poses a significant diagnostic challenge often leading to a delay in the initiation of appropriate treatment. We describe a case of a rapidly deteriorating clinical course in a child with central nervous system ALCL and review the current literature on ALCL occurring in the central nervous system.
Full Text
Duke Authors
Cited Authors
- Karikari, IO; Thomas, KK; Lagoo, A; Cummings, TJ; George, TM
Published Date
- 2007
Published In
Volume / Issue
- 43 / 6
Start / End Page
- 516 - 521
PubMed ID
- 17992044
Electronic International Standard Serial Number (EISSN)
- 1423-0305
Digital Object Identifier (DOI)
- 10.1159/000108799
Language
- eng
Conference Location
- Switzerland