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Cholesterol granuloma of the lateral ventricle. Case report.

Publication ,  Journal Article
Grossi, PM; Ellis, MJ; Cummings, TJ; Gray, LL; Fukushima, T; Sampson, JH
Published in: J Neurosurg
February 2008

Cholesterol granulomas (CGs) are benign lesions resulting from an inflammatory reaction to cholesterol and hemosiderin. These masses most often arise within the temporal bone or nasal sinuses; intracerebral CGs are extremely rare. In this report the authors present an unusual case of a CG arising within the lateral ventricle. The patient presented with transient hemiparesis and numbness. Computed tomography and magnetic resonance imaging demonstrated a cystic partially enhancing midline mass within the right lateral ventricle, expanding the ventricle and displacing the septum pellucidum. The patient underwent an interhemispheric, transcallosal resection of the lesion. Microscopic examination revealed a granulomatous inflammatory lesion containing cholesterol clefts, macrophages, and hemosiderin. Embedded within the granulomatous response were foci of tiny cystlike structures lined by nonciliated flattened cuboidal epithelium, consistent with the diagnosis of CG. To the authors' knowledge this is the first reported case of CG presenting as an intraventricular mass. The origin of this lesion is unclear, but it may relate to prior traumatic brain injury. The authors describe the presentation, imaging findings, histopathological characteristics, and surgical treatment of this rare lesion and related pathological entities.

Duke Scholars

Published In

J Neurosurg

DOI

ISSN

0022-3085

Publication Date

February 2008

Volume

108

Issue

2

Start / End Page

357 / 360

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Septum Pellucidum
  • Paresis
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Macrophages
  • Lateral Ventricles
  • Hypesthesia
 

Citation

APA
Chicago
ICMJE
MLA
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Grossi, P. M., Ellis, M. J., Cummings, T. J., Gray, L. L., Fukushima, T., & Sampson, J. H. (2008). Cholesterol granuloma of the lateral ventricle. Case report. J Neurosurg, 108(2), 357–360. https://doi.org/10.3171/JNS/2008/108/2/0357
Grossi, Peter M., Michael J. Ellis, Thomas J. Cummings, Linda L. Gray, Takanori Fukushima, and John H. Sampson. “Cholesterol granuloma of the lateral ventricle. Case report.J Neurosurg 108, no. 2 (February 2008): 357–60. https://doi.org/10.3171/JNS/2008/108/2/0357.
Grossi PM, Ellis MJ, Cummings TJ, Gray LL, Fukushima T, Sampson JH. Cholesterol granuloma of the lateral ventricle. Case report. J Neurosurg. 2008 Feb;108(2):357–60.
Grossi, Peter M., et al. “Cholesterol granuloma of the lateral ventricle. Case report.J Neurosurg, vol. 108, no. 2, Feb. 2008, pp. 357–60. Pubmed, doi:10.3171/JNS/2008/108/2/0357.
Grossi PM, Ellis MJ, Cummings TJ, Gray LL, Fukushima T, Sampson JH. Cholesterol granuloma of the lateral ventricle. Case report. J Neurosurg. 2008 Feb;108(2):357–360.

Published In

J Neurosurg

DOI

ISSN

0022-3085

Publication Date

February 2008

Volume

108

Issue

2

Start / End Page

357 / 360

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Septum Pellucidum
  • Paresis
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Macrophages
  • Lateral Ventricles
  • Hypesthesia