Preoperative diagnosis of a mediastinal granular cell tumor by EUS-FNA: a case report and review of the literature.

Journal Article

We report the first case of a posterior mediastinal granular cell tumor initially diagnosed on cytologic material obtained via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in a 51-year-old male with a prior history of colon cancer. Aspirates obtained were cellular and composed of polygonal cells with abundant granular cytoplasm and small, round dark nuclei. An immunoperoxidase stain performed on the cell block for antibodies to S-100 protein showed strong, diffuse staining of the cytoplasmic granules. Electron microscopy performed on the cell block revealed numerous cytoplasmic lysosomes. This is the first case report in the English literature of a definitive preoperative diagnosis of a mediastinal granular cell tumor utilizing material obtained via EUS-FNA.

Full Text

Duke Authors

Cited Authors

  • Bean, SM; Eloubeidi, MA; Eltoum, IA; Cerfolio, RJ; Jhala, DN

Published Date

  • June 8, 2005

Published In

Volume / Issue

  • 2 / 1

Start / End Page

  • 8 -

PubMed ID

  • 15943858

Pubmed Central ID

  • 15943858

Electronic International Standard Serial Number (EISSN)

  • 1742-6413

Digital Object Identifier (DOI)

  • 10.1186/1742-6413-2-8


  • eng

Conference Location

  • United States