Intermolecular hydroamination of allenes with N-unsubstituted carbamates catalyzed by a gold(I) N-heterocyclic carbene complex.
Journal Article
Reaction of 2,3-pentadienyl benzoate with benzyl carbamate catalyzed by a 1:1 mixture of (NHC)AuCl and AgOTf in dioxane at 23 degrees C for 5 h led to isolation of (E)-4-(benzyloxycarbonylamino)-2-pentenyl benzoate in 84% yield as a single regio- and diastereomer. Gold(I)-catalyzed hydroamination was effective for a number of N-unsubstituted carbamates and a range of substituted allenes.
Full Text
Duke Authors
Cited Authors
- Kinder, RE; Zhang, Z; Widenhoefer, RA
Published Date
- July 2008
Published In
Volume / Issue
- 10 / 14
Start / End Page
- 3157 - 3159
PubMed ID
- 18570376
Pubmed Central ID
- 18570376
Electronic International Standard Serial Number (EISSN)
- 1523-7052
International Standard Serial Number (ISSN)
- 1523-7060
Digital Object Identifier (DOI)
- 10.1021/ol8010858
Language
- eng