Differential effects of methamphetamine and haloperidol on the control of an internal clock.


Journal Article

Humans and animals process temporal information as if they were using an internal stopwatch that can be stopped and reset, and whose speed is adjustable. Previous data suggest that dopaminergic drugs affect the speed of this internal stopwatch. Using a paradigm in which rats have to filter out the gaps that (sometimes) interrupted timing, the authors found that methamphetamine and haloperidol also affect the stop and reset mechanism of the internal clock, possibly by modulating attentional components that are dependent on the content and salience of the timed events. This is the first report of both clock and attentional effects of dopaminergic drugs on interval timing in the same experimental setting.

Full Text

Cited Authors

  • Buhusi, CV; Meck, WH

Published Date

  • April 2002

Published In

Volume / Issue

  • 116 / 2

Start / End Page

  • 291 - 297

PubMed ID

  • 11996314

Pubmed Central ID

  • 11996314

Electronic International Standard Serial Number (EISSN)

  • 1939-0084

International Standard Serial Number (ISSN)

  • 0735-7044

Digital Object Identifier (DOI)

  • 10.1037//0735-7044.116.2.291


  • eng