The use of timing behaviors in animals and humans to detect drug and/or toxicant effects.

Published

Journal Article

Behavioral paradigms applicable for use in both human and nonhuman subjects for investigating aspects of timing behavior are presented with a view towards exploring their strengths, weaknesses, and utility in a variety of experimental situations. Tri-peak, peak interval, differential reinforcement of low rate responding, and temporal response differentiation procedures are highlighted. In addition, the application of timing tasks in preclinical and clinical settings is discussed: pharmacological manipulations are providing information on the neurotransmitters involved and species differences; normative data for children are being developed; and noninvasive imaging procedures are being employed in adult human subjects to explore the involvement of specific brain areas.

Full Text

Duke Authors

Cited Authors

  • Paule, MG; Meck, WH; McMillan, DE; McClure, GY; Bateson, M; Popke, EJ; Chelonis, JJ; Hinton, SC

Published Date

  • September 1999

Published In

Volume / Issue

  • 21 / 5

Start / End Page

  • 491 - 502

PubMed ID

  • 10492384

Pubmed Central ID

  • 10492384

Electronic International Standard Serial Number (EISSN)

  • 1872-9738

International Standard Serial Number (ISSN)

  • 0892-0362

Digital Object Identifier (DOI)

  • 10.1016/s0892-0362(99)00015-x

Language

  • eng