The use of timing behaviors in animals and humans to detect drug and/or toxicant effects.
Behavioral paradigms applicable for use in both human and nonhuman subjects for investigating aspects of timing behavior are presented with a view towards exploring their strengths, weaknesses, and utility in a variety of experimental situations. Tri-peak, peak interval, differential reinforcement of low rate responding, and temporal response differentiation procedures are highlighted. In addition, the application of timing tasks in preclinical and clinical settings is discussed: pharmacological manipulations are providing information on the neurotransmitters involved and species differences; normative data for children are being developed; and noninvasive imaging procedures are being employed in adult human subjects to explore the involvement of specific brain areas.
Paule, MG; Meck, WH; McMillan, DE; McClure, GY; Bateson, M; Popke, EJ; Chelonis, JJ; Hinton, SC
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