Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons.

Published

Journal Article

This study investigated the firing patterns of striatal and cortical neurons in rats in a temporal generalization task. Striatal and cortical ensembles were recorded in rats trained to lever press at 2 possible criterion durations (10 s or 40 s from tone onset). Twenty-two percent of striatal and 15% of cortical cells had temporally specific modulations in their firing rate, firing at a significantly different rate around 10 s compared with 40 s. On 80% of trials, a post hoc analysis of the trial-by-trial consistency of the firing rates of an ensemble of neurons predicted whether a spike train came from a time window around 10 s versus around 40 s. Results suggest that striatal and cortical neurons encode specific durations in their firing rate and thereby serve as components of a neural circuit used to represent duration.

Full Text

Duke Authors

Cited Authors

  • Matell, MS; Meck, WH; Nicolelis, MAL

Published Date

  • August 2003

Published In

Volume / Issue

  • 117 / 4

Start / End Page

  • 760 - 773

PubMed ID

  • 12931961

Pubmed Central ID

  • 12931961

International Standard Serial Number (ISSN)

  • 0735-7044

Language

  • eng

Conference Location

  • United States