Interaction of raclopride and preparatory interval effects on simple reaction time performance.


Journal Article

In a series of three experiments, simple reaction time (RT) was characterized with respect to a variable preparatory interval (PI) in order to investigate the relationship between interval timing and RT. In Experiment 1, it was shown that RT decreases as a function of PI and that this effect varies with amount of training. In Experiment 2, RT was shown to increase during probe trials that used a novel 6.25s PI, suggesting that the specific durations of the PIs encoded during initial training contribute to the PI effect on RT. In Experiment 3, 100 microg/kg i.p. of raclopride proportionally slowed RT as a function of the PI. These results are discussed within the context of neuropsychological models of interval timing and support an underlying role for cortico-striatal dopaminergic function in temporal processing and simple RT measurements.

Full Text

Cited Authors

  • Macdonald, CJ; Meck, WH

Published Date

  • November 2006

Published In

Volume / Issue

  • 175 / 1

Start / End Page

  • 62 - 74

PubMed ID

  • 16962181

Pubmed Central ID

  • 16962181

Electronic International Standard Serial Number (EISSN)

  • 1872-7549

International Standard Serial Number (ISSN)

  • 0166-4328

Digital Object Identifier (DOI)

  • 10.1016/j.bbr.2006.08.004


  • eng