Prenatal-choline supplementation differentially modulates timing of auditory and visual stimuli in aged rats.

Journal Article (Journal Article)

Choline supplementation of the maternal diet has a long-term facilitative effect on the interval-timing ability and temporal memory of the offspring. Here, we examined whether prenatal-choline supplementation has modality-specific effects on duration discrimination in aged (20 mo) male rats. Adult offspring of rats that were given sufficient choline in their chow (CON: 1.1 g/kg) or supplemental choline added to their drinking water (SUP: 3.5 g/kg) during embryonic days (ED) 12-17 were trained and tested on a two-modality (auditory and visual signals) duration bisection procedure (2 s vs. 8 s). Intensity (high vs. low) of the auditory and visual timing signals was systematically manipulated across test sessions such that all combinations of signal intensity by modality were tested. Psychometric response functions indicated that prenatal-choline supplementation systematically increased sensitivity to auditory signals relative to visual signals, thereby magnifying the modality effect that sounds are judged to be longer than lights of equivalent duration. In addition, sensitivity to signal duration was greater in rats given prenatal-choline supplementation, particularly at low intensities of both the auditory and visual signals. Overall, these results suggest that prenatal-choline supplementation impacts interval timing by enhancing the differences in temporal integration between auditory and visual stimuli in aged subjects.

Full Text

Duke Authors

Cited Authors

  • Cheng, R-K; Scott, AC; Penney, TB; Williams, CL; Meck, WH

Published Date

  • October 2008

Published In

Volume / Issue

  • 1237 /

Start / End Page

  • 167 - 175

PubMed ID

  • 18801344

Electronic International Standard Serial Number (EISSN)

  • 1872-6240

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/j.brainres.2008.08.062


  • eng