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Polymersomes: a new multi-functional tool for cancer diagnosis and therapy.

Publication ,  Journal Article
Levine, DH; Ghoroghchian, PP; Freudenberg, J; Zhang, G; Therien, MJ; Greene, MI; Hammer, DA; Murali, R
Published in: Methods (San Diego, Calif.)
September 2008

Nanoparticles are being developed as delivery vehicles for therapeutic pharmaceuticals and contrast imaging agents. Polymersomes (mesoscopic polymer vesicles) possess a number of attractive biomaterial properties that make them ideal for these applications. Synthetic control over block copolymer chemistry enables tunable design of polymersome material properties. The polymersome architecture, with its large hydrophilic reservoir and its thick hydrophobic lamellar membrane, provides significant storage capacity for both water soluble and insoluble substances (such as drugs and imaging probes). Further, the brush-like architecture of the polymersome outer shell can potentially increase biocompatibility and blood circulation times. A further recent advance is the development of multi-functional polymersomes that carry pharmaceuticals and imaging agents simultaneously. The ability to conjugate biologically active ligands to the brush surface provides a further means for targeted therapy and imaging. Hence, polymersomes hold enormous potential as nanostructured biomaterials for future in vivo drug delivery and diagnostic imaging applications.

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Published In

Methods (San Diego, Calif.)

DOI

EISSN

1095-9130

ISSN

1046-2023

Publication Date

September 2008

Volume

46

Issue

1

Start / End Page

25 / 32

Related Subject Headings

  • Solubility
  • Polymers
  • Neoplasms
  • Nanoparticles
  • Nanomedicine
  • Molecular Probes
  • Micelles
  • Humans
  • Drug Carriers
  • Diagnostic Imaging
 

Citation

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ICMJE
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Levine, D. H., Ghoroghchian, P. P., Freudenberg, J., Zhang, G., Therien, M. J., Greene, M. I., … Murali, R. (2008). Polymersomes: a new multi-functional tool for cancer diagnosis and therapy. Methods (San Diego, Calif.), 46(1), 25–32. https://doi.org/10.1016/j.ymeth.2008.05.006
Levine, Dalia Hope, P Peter Ghoroghchian, Jaclyn Freudenberg, Geng Zhang, Michael J. Therien, Mark I. Greene, Daniel A. Hammer, and Ramachandran Murali. “Polymersomes: a new multi-functional tool for cancer diagnosis and therapy.Methods (San Diego, Calif.) 46, no. 1 (September 2008): 25–32. https://doi.org/10.1016/j.ymeth.2008.05.006.
Levine DH, Ghoroghchian PP, Freudenberg J, Zhang G, Therien MJ, Greene MI, et al. Polymersomes: a new multi-functional tool for cancer diagnosis and therapy. Methods (San Diego, Calif). 2008 Sep;46(1):25–32.
Levine, Dalia Hope, et al. “Polymersomes: a new multi-functional tool for cancer diagnosis and therapy.Methods (San Diego, Calif.), vol. 46, no. 1, Sept. 2008, pp. 25–32. Epmc, doi:10.1016/j.ymeth.2008.05.006.
Levine DH, Ghoroghchian PP, Freudenberg J, Zhang G, Therien MJ, Greene MI, Hammer DA, Murali R. Polymersomes: a new multi-functional tool for cancer diagnosis and therapy. Methods (San Diego, Calif). 2008 Sep;46(1):25–32.
Journal cover image

Published In

Methods (San Diego, Calif.)

DOI

EISSN

1095-9130

ISSN

1046-2023

Publication Date

September 2008

Volume

46

Issue

1

Start / End Page

25 / 32

Related Subject Headings

  • Solubility
  • Polymers
  • Neoplasms
  • Nanoparticles
  • Nanomedicine
  • Molecular Probes
  • Micelles
  • Humans
  • Drug Carriers
  • Diagnostic Imaging