Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.

Published

Journal Article

Quinoid inhibitors of Cdc25B were designed based on the Linear Combination of Atomic Potentials (LCAP) methodology. In contrast to a published hypothesis, the biological activities and hydrogen peroxide generation in reducing media of three synthetic models did not correlate with the quinone half-wave potential, E(1/2).

Full Text

Duke Authors

Cited Authors

  • Keinan, S; Paquette, WD; Skoko, JJ; Beratan, DN; Yang, W; Shinde, S; Johnston, PA; Lazo, JS; Wipf, P

Published Date

  • September 2008

Published In

Volume / Issue

  • 6 / 18

Start / End Page

  • 3256 - 3263

PubMed ID

  • 18802630

Pubmed Central ID

  • 18802630

Electronic International Standard Serial Number (EISSN)

  • 1477-0539

International Standard Serial Number (ISSN)

  • 1477-0520

Digital Object Identifier (DOI)

  • 10.1039/b806712k

Language

  • eng