Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.
Published
Journal Article
Quinoid inhibitors of Cdc25B were designed based on the Linear Combination of Atomic Potentials (LCAP) methodology. In contrast to a published hypothesis, the biological activities and hydrogen peroxide generation in reducing media of three synthetic models did not correlate with the quinone half-wave potential, E(1/2).
Full Text
Duke Authors
Cited Authors
- Keinan, S; Paquette, WD; Skoko, JJ; Beratan, DN; Yang, W; Shinde, S; Johnston, PA; Lazo, JS; Wipf, P
Published Date
- September 2008
Published In
Volume / Issue
- 6 / 18
Start / End Page
- 3256 - 3263
PubMed ID
- 18802630
Pubmed Central ID
- 18802630
Electronic International Standard Serial Number (EISSN)
- 1477-0539
International Standard Serial Number (ISSN)
- 1477-0520
Digital Object Identifier (DOI)
- 10.1039/b806712k
Language
- eng