Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.
Journal Article (Journal Article)
A facile synthetic route to substituted trans-2-arylcyclopropylamines was developed to provide access to mechanism-based inhibitors of the human flavoenzyme oxidase lysine-specific histone demethylase LSD1 and related enzyme family members such as monoamine oxidases A and B.
Full Text
Duke Authors
Cited Authors
- Gooden, DM; Schmidt, DMZ; Pollock, JA; Kabadi, AM; McCafferty, DG
Published Date
- May 2008
Published In
Volume / Issue
- 18 / 10
Start / End Page
- 3047 - 3051
PubMed ID
- 18242989
Pubmed Central ID
- PMC2661354
Electronic International Standard Serial Number (EISSN)
- 1464-3405
International Standard Serial Number (ISSN)
- 0960-894X
Digital Object Identifier (DOI)
- 10.1016/j.bmcl.2008.01.003
Language
- eng