Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.

Journal Article (Journal Article)

A facile synthetic route to substituted trans-2-arylcyclopropylamines was developed to provide access to mechanism-based inhibitors of the human flavoenzyme oxidase lysine-specific histone demethylase LSD1 and related enzyme family members such as monoamine oxidases A and B.

Full Text

Duke Authors

Cited Authors

  • Gooden, DM; Schmidt, DMZ; Pollock, JA; Kabadi, AM; McCafferty, DG

Published Date

  • May 2008

Published In

Volume / Issue

  • 18 / 10

Start / End Page

  • 3047 - 3051

PubMed ID

  • 18242989

Pubmed Central ID

  • PMC2661354

Electronic International Standard Serial Number (EISSN)

  • 1464-3405

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2008.01.003

Language

  • eng