Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.

Journal Article (Journal Article)

A facile synthetic route to substituted trans-2-arylcyclopropylamines was developed to provide access to mechanism-based inhibitors of the human flavoenzyme oxidase lysine-specific histone demethylase LSD1 and related enzyme family members such as monoamine oxidases A and B.

Full Text

Duke Authors

McCafferty, Dewey G.

Cited Authors

Gooden, DM; Schmidt, DMZ; Pollock, JA; Kabadi, AM; McCafferty, DG

Published Date

May 2008

Published In

Bioorganic & Medicinal Chemistry Letters

Volume / Issue

18 / 10

Start / End Page

3047 - 3051

PubMed ID

18242989

Pubmed Central ID

PMC2661354

Electronic International Standard Serial Number (EISSN)

1464-3405

International Standard Serial Number (ISSN)

0960-894X

Digital Object Identifier (DOI)

10.1016/j.bmcl.2008.01.003

Language

eng