Thrombotic thrombocytopenic purpura induced by trimethoprim-sulfamethoxazole in a Jehovah's Witness.
Journal Article (Journal Article)
We report a case of Thrombotic Thrombocytopenic Purpura occurring as an allergic response to trimethoprim-sulfamethoxazole therapy (Bactrim, Septra) in a Jehovah's Witness patient. The patient presented with fulminant microangiopathic hemolytic anemia and thrombocytopenia within 48 hr of initiating therapy with trimethoprim-sulfamethoxazole. Other symptoms of drug hypersensitivity included nausea, vomiting, urticarial rash, and leukopenia. Because of her religious faith, the patient was supported without plasma therapy with use of intravenous immunoglobulin, steroids, rituximab, and erythropoietin.
Full Text
Duke Authors
Cited Authors
- Martin, MG; Whitlatch, NL; Shah, B; Arepally, GM
Published Date
- July 2007
Published In
Volume / Issue
- 82 / 7
Start / End Page
- 679 - 681
PubMed ID
- 17266059
International Standard Serial Number (ISSN)
- 0361-8609
Digital Object Identifier (DOI)
- 10.1002/ajh.20887
Language
- eng
Conference Location
- United States