Transplantation-mediated alloimmune thrombocytopenia: Guidelines for utilization of thrombocytopenic donors.
Transplantation-mediated alloimmune thrombocytopenia (TMAT) is donor-derived thrombocytopenia following solid-organ transplantation. To date, no clear consensus on the appropriateness of organ utilization from cadaver donors with a history of idiopathic thrombocytopenia purpura (ITP) has emerged. Herein is reported a devastating case of TMAT following liver transplantation utilizing an allograft from a donor with ITP that resulted in allograft failure. The literature is reviewed in this context to propose preliminary guidelines regarding utilization of allografts from cadaver donors with a history of ITP.
Diaz, GC; Prowda, J; Lo, IJ; Arepally, GM; Evans, N; Wheeless, Y; Samstein, B; Guarrera, JV; Renz, JF
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