Analysis of laterality and percentage of tumor involvement in 1386 prostatectomized specimens for selection of unilateral focal cryotherapy.


Journal Article

In total, 1386 paraffin embedded radical prostatectomy specimens from patients with clinically localized prostate cancer (PCa) excised between 2002-06 were analyzed. Pathologic assessment paid particular attention to laterality and percentage of tumor involvement (PTI) along with pathologic Gleason Score (pGS). Completely unilateral cancers were identified in 254 (18.3%) patients, and in 39% cases of them the signs of clinically significant PCa were revealed. The majority of unilateral tumors (72%) were low volume with a PTI of < or =5. This study suggests that only a select group of men diagnosed with PCa have completely unilateral cancers that would be amenable to focal ablation therapy targeting 1 lobe. Further study is needed to develop predictive models for those patients likely to have small, unilateral cancers that may be amenable to focal therapy.

Full Text

Duke Authors

Cited Authors

  • Mouraviev, V; Mayes, JM; Madden, JF; Sun, L; Polascik, TJ

Published Date

  • April 2007

Published In

Volume / Issue

  • 6 / 2

Start / End Page

  • 91 - 95

PubMed ID

  • 17375971

Pubmed Central ID

  • 17375971

International Standard Serial Number (ISSN)

  • 1533-0346

Digital Object Identifier (DOI)

  • 10.1177/153303460700600205


  • eng

Conference Location

  • United States