A small molecule inhibitor of alpha4 integrin-dependent cell migration.
Journal Article (Journal Article)
A small molecule inhibitor of alpha4 integrin-dependent cell migration was identified through a cell-based screen of small molecule libraries. Biochemical and cellular experiments suggest that this molecule functions by interacting with gamma-parvin. This molecule should serve as a useful tool to study alpha4 integrin signaling and may lead to new therapeutics for the treatment of autoimmune diseases.
- Lee, J; Hong, J; Nam, T-G; Peters, EC; Orth, AP; Geierstanger, BH; Goldfinger, LE; Ginsberg, MH; Cho, CY; Schultz, PG
- February 2009
Volume / Issue
- 17 / 3
Start / End Page
- 977 - 980
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)