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A small molecule inhibitor of alpha4 integrin-dependent cell migration.

Publication ,  Journal Article
Lee, J; Hong, J; Nam, T-G; Peters, EC; Orth, AP; Geierstanger, BH; Goldfinger, LE; Ginsberg, MH; Cho, CY; Schultz, PG
Published in: Bioorganic & medicinal chemistry
February 2009

A small molecule inhibitor of alpha4 integrin-dependent cell migration was identified through a cell-based screen of small molecule libraries. Biochemical and cellular experiments suggest that this molecule functions by interacting with gamma-parvin. This molecule should serve as a useful tool to study alpha4 integrin signaling and may lead to new therapeutics for the treatment of autoimmune diseases.

Duke Scholars

Published In

Bioorganic & medicinal chemistry

DOI

EISSN

1464-3391

ISSN

0968-0896

Publication Date

February 2009

Volume

17

Issue

3

Start / End Page

977 / 980

Related Subject Headings

  • Tubercidin
  • Small Molecule Libraries
  • Signal Transduction
  • RNA Interference
  • Medicinal & Biomolecular Chemistry
  • Jurkat Cells
  • Integrin alpha4
  • Humans
  • Cricetulus
  • Cricetinae
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lee, J., Hong, J., Nam, T.-G., Peters, E. C., Orth, A. P., Geierstanger, B. H., … Schultz, P. G. (2009). A small molecule inhibitor of alpha4 integrin-dependent cell migration. Bioorganic & Medicinal Chemistry, 17(3), 977–980. https://doi.org/10.1016/j.bmc.2008.02.067
Lee, Jongkook, Jiyong Hong, Tae-Gyu Nam, Eric C. Peters, Anthony P. Orth, Bernhard H. Geierstanger, Lawrence E. Goldfinger, Mark H. Ginsberg, Charles Y. Cho, and Peter G. Schultz. “A small molecule inhibitor of alpha4 integrin-dependent cell migration.Bioorganic & Medicinal Chemistry 17, no. 3 (February 2009): 977–80. https://doi.org/10.1016/j.bmc.2008.02.067.
Lee J, Hong J, Nam T-G, Peters EC, Orth AP, Geierstanger BH, et al. A small molecule inhibitor of alpha4 integrin-dependent cell migration. Bioorganic & medicinal chemistry. 2009 Feb;17(3):977–80.
Lee, Jongkook, et al. “A small molecule inhibitor of alpha4 integrin-dependent cell migration.Bioorganic & Medicinal Chemistry, vol. 17, no. 3, Feb. 2009, pp. 977–80. Epmc, doi:10.1016/j.bmc.2008.02.067.
Lee J, Hong J, Nam T-G, Peters EC, Orth AP, Geierstanger BH, Goldfinger LE, Ginsberg MH, Cho CY, Schultz PG. A small molecule inhibitor of alpha4 integrin-dependent cell migration. Bioorganic & medicinal chemistry. 2009 Feb;17(3):977–980.
Journal cover image

Published In

Bioorganic & medicinal chemistry

DOI

EISSN

1464-3391

ISSN

0968-0896

Publication Date

February 2009

Volume

17

Issue

3

Start / End Page

977 / 980

Related Subject Headings

  • Tubercidin
  • Small Molecule Libraries
  • Signal Transduction
  • RNA Interference
  • Medicinal & Biomolecular Chemistry
  • Jurkat Cells
  • Integrin alpha4
  • Humans
  • Cricetulus
  • Cricetinae