A small molecule inhibitor of alpha4 integrin-dependent cell migration.

Published

Journal Article

A small molecule inhibitor of alpha4 integrin-dependent cell migration was identified through a cell-based screen of small molecule libraries. Biochemical and cellular experiments suggest that this molecule functions by interacting with gamma-parvin. This molecule should serve as a useful tool to study alpha4 integrin signaling and may lead to new therapeutics for the treatment of autoimmune diseases.

Full Text

Duke Authors

Cited Authors

  • Lee, J; Hong, J; Nam, T-G; Peters, EC; Orth, AP; Geierstanger, BH; Goldfinger, LE; Ginsberg, MH; Cho, CY; Schultz, PG

Published Date

  • February 2009

Published In

Volume / Issue

  • 17 / 3

Start / End Page

  • 977 - 980

PubMed ID

  • 18329275

Pubmed Central ID

  • 18329275

Electronic International Standard Serial Number (EISSN)

  • 1464-3391

International Standard Serial Number (ISSN)

  • 0968-0896

Digital Object Identifier (DOI)

  • 10.1016/j.bmc.2008.02.067

Language

  • eng