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Estrogen bioactivation, genetic polymorphisms, and ovarian cancer.

Publication ,  Journal Article
Sellers, TA; Schildkraut, JM; Pankratz, VS; Vierkant, RA; Fredericksen, ZS; Olson, JE; Cunningham, J; Taylor, W; Liebow, M; McPherson, C ...
Published in: Cancer Epidemiol Biomarkers Prev
November 2005

Recent experimental evidence has shown that catechol estrogens can be activated through metabolism to form depurinating DNA adducts and thereby initiate cancer. Limited data are available regarding this pathway in epithelial ovarian cancer. We conducted a case-control study of 503 incident epithelial ovarian cancer cases at the Mayo Clinic in Rochester, MN, and Jacksonville, FL, and a 48-county region in North Carolina. Six hundred nine cancer-free controls were frequency matched to the cases on age, race, and residence. After an interview to obtain data on risk factors, a sample of blood was collected for DNA isolation. Subjects were genotyped for seven common single nucleotide polymorphisms in four genes involved in catechol estrogen formation (CYP1A1 and CYP1B1) or conjugation (COMT and SULT1A1). Data were analyzed using logistic regression, stratified by race, and with adjustment for design factors and potential confounders. None of the individual genotypes were significantly associated with ovarian cancer risk. However, an oligogenic model that considered the joint effects of the four candidate genes provided evidence for an association between combinations of these genes and ovarian cancer status (P = 0.015). Although preliminary, this study provides some support for the hypothesis that low-penetrance susceptibility alleles may influence risk of epithelial ovarian cancer.

Duke Scholars

Published In

Cancer Epidemiol Biomarkers Prev

DOI

ISSN

1055-9965

Publication Date

November 2005

Volume

14

Issue

11 Pt 1

Start / End Page

2536 / 2543

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Genetic
  • Ovarian Neoplasms
  • Middle Aged
  • Humans
  • Genotype
  • Female
  • Estrogens
  • Epidemiology
  • Case-Control Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Sellers, T. A., Schildkraut, J. M., Pankratz, V. S., Vierkant, R. A., Fredericksen, Z. S., Olson, J. E., … Adjei, A. A. (2005). Estrogen bioactivation, genetic polymorphisms, and ovarian cancer. Cancer Epidemiol Biomarkers Prev, 14(11 Pt 1), 2536–2543. https://doi.org/10.1158/1055-9965.EPI-05-0142
Sellers, Thomas A., Joellen M. Schildkraut, V Shane Pankratz, Robert A. Vierkant, Zachary S. Fredericksen, Janet E. Olson, Julie Cunningham, et al. “Estrogen bioactivation, genetic polymorphisms, and ovarian cancer.Cancer Epidemiol Biomarkers Prev 14, no. 11 Pt 1 (November 2005): 2536–43. https://doi.org/10.1158/1055-9965.EPI-05-0142.
Sellers TA, Schildkraut JM, Pankratz VS, Vierkant RA, Fredericksen ZS, Olson JE, et al. Estrogen bioactivation, genetic polymorphisms, and ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2005 Nov;14(11 Pt 1):2536–43.
Sellers, Thomas A., et al. “Estrogen bioactivation, genetic polymorphisms, and ovarian cancer.Cancer Epidemiol Biomarkers Prev, vol. 14, no. 11 Pt 1, Nov. 2005, pp. 2536–43. Pubmed, doi:10.1158/1055-9965.EPI-05-0142.
Sellers TA, Schildkraut JM, Pankratz VS, Vierkant RA, Fredericksen ZS, Olson JE, Cunningham J, Taylor W, Liebow M, McPherson C, Hartmann LC, Pal T, Adjei AA. Estrogen bioactivation, genetic polymorphisms, and ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2005 Nov;14(11 Pt 1):2536–2543.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

ISSN

1055-9965

Publication Date

November 2005

Volume

14

Issue

11 Pt 1

Start / End Page

2536 / 2543

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Genetic
  • Ovarian Neoplasms
  • Middle Aged
  • Humans
  • Genotype
  • Female
  • Estrogens
  • Epidemiology
  • Case-Control Studies