Association between low levels of 1,25-dihydroxyvitamin D and breast cancer risk.

Journal Article (Journal Article)

OBJECTIVE: To determine if blood levels of 25-hydroxyvitamin D (25-D) or its active metabolite, 1,25-dihydroxyvitamin D (1,25-D), are lower in women at the time of first diagnosis of breast cancer than in comparable women without breast cancer. DESIGN: This was a clinic-based case-control study with controls frequency-matched to cases on race, age, clinic and month of blood drawing. SETTING: University-based breast referral clinics. SUBJECTS: One hundred and fifty-six women with histologically documented adenocarcinoma of the breast and 184 breast clinic controls. RESULTS: There were significant mean differences in 1,25-D levels (pmol ml(-1)) between breast cancer cases and controls; white cases had lower 1,25-D levels than white controls (mean difference +/-SE: -11.08+/-0.76), and black cases had higher 1.25-D levels than black controls (mean difference +/-SE: 4.54+/-2.14), although the number of black women in the study was small. After adjustment for age, assay batch, month of blood draw, clinic and sample storage time, the odds ratio (95% confidence interval, CI) for lowest relative to highest quartile was 5.2 (95% CI 2.1, 12.8) for white cases and controls. The association in white women was stronger in women above the median age of 54 than in younger women, 4.7 (95% CI 2.1, 10.2) vs. 1.5 (95% CI 0.7, 3.0). There were no case-control differences in 25-D levels in either group. CONCLUSIONS: These data are consistent with a protective effect of 1,25-D for breast cancer in white women.

Full Text

Duke Authors

Cited Authors

  • Janowsky, EC; Lester, GE; Weinberg, CR; Millikan, RC; Schildkraut, JM; Garrett, PA; Hulka, BS

Published Date

  • September 1999

Published In

Volume / Issue

  • 2 / 3

Start / End Page

  • 283 - 291

PubMed ID

  • 10512563

International Standard Serial Number (ISSN)

  • 1368-9800

Digital Object Identifier (DOI)

  • 10.1017/s1368980099000385


  • eng

Conference Location

  • England