Purification and reconstitution of the calcium release channel from skeletal muscle.
Journal Article (Journal Article)
The calcium release channel from rabbit muscle sarcoplasmic reticulum (SR) has been purified and reconstituted as a functional unit in lipid bilayers. Electron microscopy reveals the four-leaf clover structure previously described for the 'feet' that span the transverse tubule (T)-SR junction. Ca2+ release from the SR induced by T-system depolarization during excitation-contraction coupling in muscle may thus be effected through a direct association of the T-system with SR Ca2+-release channels.
Full Text
Duke Authors
Cited Authors
- Lai, FA; Erickson, HP; Rousseau, E; Liu, QY; Meissner, G
Published Date
- January 28, 1988
Published In
Volume / Issue
- 331 / 6154
Start / End Page
- 315 - 319
PubMed ID
- 2448641
International Standard Serial Number (ISSN)
- 0028-0836
Digital Object Identifier (DOI)
- 10.1038/331315a0
Language
- eng
Conference Location
- England