Purification and reconstitution of the calcium release channel from skeletal muscle.


Journal Article

The calcium release channel from rabbit muscle sarcoplasmic reticulum (SR) has been purified and reconstituted as a functional unit in lipid bilayers. Electron microscopy reveals the four-leaf clover structure previously described for the 'feet' that span the transverse tubule (T)-SR junction. Ca2+ release from the SR induced by T-system depolarization during excitation-contraction coupling in muscle may thus be effected through a direct association of the T-system with SR Ca2+-release channels.

Full Text

Duke Authors

Cited Authors

  • Lai, FA; Erickson, HP; Rousseau, E; Liu, QY; Meissner, G

Published Date

  • January 28, 1988

Published In

Volume / Issue

  • 331 / 6154

Start / End Page

  • 315 - 319

PubMed ID

  • 2448641

Pubmed Central ID

  • 2448641

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/331315a0


  • eng

Conference Location

  • England