Purification and reconstitution of the calcium release channel from skeletal muscle.

Journal Article (Journal Article)

The calcium release channel from rabbit muscle sarcoplasmic reticulum (SR) has been purified and reconstituted as a functional unit in lipid bilayers. Electron microscopy reveals the four-leaf clover structure previously described for the 'feet' that span the transverse tubule (T)-SR junction. Ca2+ release from the SR induced by T-system depolarization during excitation-contraction coupling in muscle may thus be effected through a direct association of the T-system with SR Ca2+-release channels.

Full Text

Duke Authors

Cited Authors

  • Lai, FA; Erickson, HP; Rousseau, E; Liu, QY; Meissner, G

Published Date

  • January 28, 1988

Published In

Volume / Issue

  • 331 / 6154

Start / End Page

  • 315 - 319

PubMed ID

  • 2448641

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/331315a0


  • eng

Conference Location

  • England