Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis.
Journal Article (Journal Article)
Fibronectin performs essential roles in embryonic development and is prominently expressed during tissue repair. Two forms of fibronectin have been identified: plasma fibronectin (pFn), which is expressed by hepatocytes and secreted in soluble form into plasma; and cellular fibronectin (cFn), an insoluble form expressed locally by fibroblasts and other cell types and deposited and assembled into the extracellular matrix. To investigate the role of pFn in vivo, we generated pFn-deficient adult mice using Cre-loxP conditional gene-knockout technology. Here we show that pFn-deficient mice show increased neuronal apoptosis and larger infarction areas following transient focal cerebral ischemia. However, pFn is dispensable for skin-wound healing and hemostasis.
Full Text
Duke Authors
Cited Authors
- Sakai, T; Johnson, KJ; Murozono, M; Sakai, K; Magnuson, MA; Wieloch, T; Cronberg, T; Isshiki, A; Erickson, HP; Fässler, R
Published Date
- March 2001
Published In
Volume / Issue
- 7 / 3
Start / End Page
- 324 - 330
PubMed ID
- 11231631
International Standard Serial Number (ISSN)
- 1078-8956
Digital Object Identifier (DOI)
- 10.1038/85471
Language
- eng
Conference Location
- United States