Atomic structures of tubulin and FtsZ.

Journal Article (Journal Article;Review)

The recently published atomic structures of tubulin and FtsZ are a research milestone. The N-terminal GTP-binding domains of tubulin and FtsZ are virtually identical in structure, as expected from the substantial sequence identity. Sequence identity is absent from the C-terminal domains, but they also have virtually identical structures. A surprising finding is that the N-terminal GTP-binding domain is structurally homologous to that of Ras and other G proteins, despite the completely different GTP-binding sequence motifs. This article discusses these findings and the molecular mechanisms that can now be addressed with the atomic structures.

Full Text

Duke Authors

Cited Authors

  • Erickson, HP

Published Date

  • April 1998

Published In

Volume / Issue

  • 8 / 4

Start / End Page

  • 133 - 137

PubMed ID

  • 9695825

International Standard Serial Number (ISSN)

  • 0962-8924

Digital Object Identifier (DOI)

  • 10.1016/s0962-8924(98)01237-9


  • eng

Conference Location

  • England