Atomic structures of tubulin and FtsZ.
Journal Article (Journal Article;Review)
The recently published atomic structures of tubulin and FtsZ are a research milestone. The N-terminal GTP-binding domains of tubulin and FtsZ are virtually identical in structure, as expected from the substantial sequence identity. Sequence identity is absent from the C-terminal domains, but they also have virtually identical structures. A surprising finding is that the N-terminal GTP-binding domain is structurally homologous to that of Ras and other G proteins, despite the completely different GTP-binding sequence motifs. This article discusses these findings and the molecular mechanisms that can now be addressed with the atomic structures.
Full Text
Duke Authors
Cited Authors
- Erickson, HP
Published Date
- April 1998
Published In
Volume / Issue
- 8 / 4
Start / End Page
- 133 - 137
PubMed ID
- 9695825
International Standard Serial Number (ISSN)
- 0962-8924
Digital Object Identifier (DOI)
- 10.1016/s0962-8924(98)01237-9
Language
- eng
Conference Location
- England