Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain.

Journal Article (Journal Article)

A novel off-resonance rotating-frame 15N NMR spin relaxation experiment is used to characterize conformational fluctuations with correlation times between 32 and 175 microseconds in the third fibronectin type III domain of human tenascin-C. Conformational fluctuations of contiguous regions of the beta-sandwich structure of the type III domain may represent collective motions, such as transient twisting or breathing of the beta-sheets. Flexibility of the loop containing the Arg-Gly-Asp (RGD) tripeptide may affect the accessibility of this motif in protein-protein interactions.

Full Text

Duke Authors

Cited Authors

  • Akke, M; Liu, J; Cavanagh, J; Erickson, HP; Palmer, AG

Published Date

  • January 1998

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • 55 - 59

PubMed ID

  • 9437430

International Standard Serial Number (ISSN)

  • 1072-8368

Digital Object Identifier (DOI)

  • 10.1038/nsb0198-55


  • eng

Conference Location

  • United States