Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain.
Journal Article (Journal Article)
A novel off-resonance rotating-frame 15N NMR spin relaxation experiment is used to characterize conformational fluctuations with correlation times between 32 and 175 microseconds in the third fibronectin type III domain of human tenascin-C. Conformational fluctuations of contiguous regions of the beta-sandwich structure of the type III domain may represent collective motions, such as transient twisting or breathing of the beta-sheets. Flexibility of the loop containing the Arg-Gly-Asp (RGD) tripeptide may affect the accessibility of this motif in protein-protein interactions.
Full Text
Duke Authors
Cited Authors
- Akke, M; Liu, J; Cavanagh, J; Erickson, HP; Palmer, AG
Published Date
- January 1998
Published In
Volume / Issue
- 5 / 1
Start / End Page
- 55 - 59
PubMed ID
- 9437430
International Standard Serial Number (ISSN)
- 1072-8368
Digital Object Identifier (DOI)
- 10.1038/nsb0198-55
Language
- eng
Conference Location
- United States