Electron microsocpy of plasmic fragments of human fibrinogen as related to trinodular structure of the intact molecule.

Journal Article

We have examined rotary shadowed, purified plasmic fragments of human fibrinogen with the electron microscope and have determined the relation of these fragments to the intact fibrinogen molecule. Both intact fibrinogen and its earliest cleavage product, fragment X, are trinodular. The next largest product, fragment Y, consists of two linked nodules. The two terminal products, fragments D and E, are single nodules. From measurements of simultaneously shadowed specimens of these different species, we conclude that the outer nodules of the trinodular fibrinogen molecule are the fragment D-containing regions and the central nodule is the fragment E-containing region.

Full Text

Duke Authors

Cited Authors

  • Fowler, WE; Fretto, LJ; Erickson, HP; McKee, PA

Published Date

  • July 1, 1980

Published In

Volume / Issue

  • 66 / 1

Start / End Page

  • 50 - 56

PubMed ID

  • 7400308

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI109834

Language

  • eng

Conference Location

  • United States