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Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort.

Publication ,  Journal Article
Il'yasova, D; Colbert, LH; Harris, TB; Newman, AB; Bauer, DC; Satterfield, S; Kritchevsky, SB
Published in: Cancer Epidemiol Biomarkers Prev
October 2005

BACKGROUND: Chronic inflammation is associated with processes that contribute to the onset or progression of cancer. This study examined the relationships between circulating levels of the inflammatory markers interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-alpha) and total as well as site-specific cancer incidence. METHODS: Study subjects (n = 2,438) were older adults (ages 70-79 years) participating in the Health Aging and Body Composition study, who did not report a previous cancer diagnosis (except for nonmelanoma skin cancer) at baseline. Incident cancer events (n = 296) were ascertained during an average follow-up of 5.5 years. Inflammatory markers were measured in stored baseline fasting blood samples. RESULTS: The adjusted hazard ratios (95% confidence intervals) for incident cancer associated with a 1-unit increase on the natural log-scale were 1.13 (0.94-1.37), 1.25 (1.09-1.43), and 1.28 (0.96-1.70) for IL-6, CRP, and TNF-alpha, respectively. Markers were more strongly associated with cancer death: hazard ratios were 1.63 (1.19-2.23) for IL-6, 1.64 (1.20-2.24) for CRP, and 1.82 (1.14-2.92) for TNF-alpha. Although precision was low for site-specific analyses, our results suggest that all three markers were associated with lung cancer, that IL-6 and CRP were associated with colorectal cancer, and that CRP was associated with breast cancer. Prostate cancer was not associated with any of these markers. CONCLUSIONS: These findings suggest that (a) the associations between IL-6, CRP, and TNF-alpha and the risk of cancer may be site specific and (b) increased levels of inflammatory markers are more strongly associated with the risk of cancer death than cancer incidence.

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Published In

Cancer Epidemiol Biomarkers Prev

DOI

ISSN

1055-9965

Publication Date

October 2005

Volume

14

Issue

10

Start / End Page

2413 / 2418

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Risk Factors
  • Reference Values
  • Neoplasms
  • Male
  • Interleukin-6
  • Humans
  • Female
  • Epidemiology
  • C-Reactive Protein
 

Citation

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Chicago
ICMJE
MLA
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Il’yasova, D., Colbert, L. H., Harris, T. B., Newman, A. B., Bauer, D. C., Satterfield, S., & Kritchevsky, S. B. (2005). Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort. Cancer Epidemiol Biomarkers Prev, 14(10), 2413–2418. https://doi.org/10.1158/1055-9965.EPI-05-0316
Il’yasova, Dora, Lisa H. Colbert, Tamara B. Harris, Anne B. Newman, Douglas C. Bauer, Suzanne Satterfield, and Stephen B. Kritchevsky. “Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort.Cancer Epidemiol Biomarkers Prev 14, no. 10 (October 2005): 2413–18. https://doi.org/10.1158/1055-9965.EPI-05-0316.
Il’yasova D, Colbert LH, Harris TB, Newman AB, Bauer DC, Satterfield S, et al. Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort. Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2413–8.
Il’yasova, Dora, et al. “Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort.Cancer Epidemiol Biomarkers Prev, vol. 14, no. 10, Oct. 2005, pp. 2413–18. Pubmed, doi:10.1158/1055-9965.EPI-05-0316.
Il’yasova D, Colbert LH, Harris TB, Newman AB, Bauer DC, Satterfield S, Kritchevsky SB. Circulating levels of inflammatory markers and cancer risk in the health aging and body composition cohort. Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2413–2418.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

ISSN

1055-9965

Publication Date

October 2005

Volume

14

Issue

10

Start / End Page

2413 / 2418

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Risk Factors
  • Reference Values
  • Neoplasms
  • Male
  • Interleukin-6
  • Humans
  • Female
  • Epidemiology
  • C-Reactive Protein