The imprinted H19 noncoding RNA is a primary microRNA precursor.

Published

Journal Article

Although H19 was the first imprinted noncoding transcript to be identified, the function of this conserved RNA has remained unclear. Here, we identify a 23-nucleotide microRNA derived from H19 that is endogenously expressed in human keratinocytes and neonatal mice and overexpressed in cells transfected with human or mouse H19 expression plasmids. These data demonstrate that H19 can function as a primary microRNA precursor and suggest that H19 expression results in the post-transcriptional downregulation of specific mRNAs during vertebrate development.

Full Text

Duke Authors

Cited Authors

  • Cai, X; Cullen, BR

Published Date

  • March 2007

Published In

Volume / Issue

  • 13 / 3

Start / End Page

  • 313 - 316

PubMed ID

  • 17237358

Pubmed Central ID

  • 17237358

Electronic International Standard Serial Number (EISSN)

  • 1469-9001

International Standard Serial Number (ISSN)

  • 1355-8382

Digital Object Identifier (DOI)

  • 10.1261/rna.351707

Language

  • eng