Viral and cellular messenger RNA targets of viral microRNAs.


Journal Article (Review)

Given the propensity of viruses to co-opt cellular pathways and activities for their benefit, it is perhaps not surprising that several viruses have now been shown to reshape the cellular environment by reprogramming the host's RNA-interference machinery. In particular, microRNAs are produced by the various members of the herpesvirus family during both the latent stage of the viral life cycle and the lytic (or productive) stage. Emerging data suggest that viral microRNAs are particularly important for regulating the transition from latent to lytic replication and for attenuating antiviral immune responses.

Full Text

Duke Authors

Cited Authors

  • Cullen, BR

Published Date

  • January 22, 2009

Published In

Volume / Issue

  • 457 / 7228

Start / End Page

  • 421 - 425

PubMed ID

  • 19158788

Pubmed Central ID

  • 19158788

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

Digital Object Identifier (DOI)

  • 10.1038/nature07757


  • eng

Conference Location

  • England