Viral and cellular microRNAs as determinants of viral pathogenesis and immunity.

Journal Article (Journal Article;Review)

MicroRNAs (miRNAs) have recently emerged as key posttranscriptional regulators of gene expression in multicellular eukaryotes. It is increasingly clear that miRNAs of both viral and cellular origin can positively or negatively influence viral replication. Viral miRNAs can directly alter host physiology, including components of the immune system, and host miRNAs can directly alter the virus life cycle. Here, we discuss what is known about how viral and cellular miRNAs influence viral replication and pathogenic potential through their regulation of viral mRNAs or by reshaping cellular gene expression.

Full Text

Duke Authors

Cited Authors

  • Gottwein, E; Cullen, BR

Published Date

  • June 12, 2008

Published In

Volume / Issue

  • 3 / 6

Start / End Page

  • 375 - 387

PubMed ID

  • 18541214

Pubmed Central ID

  • PMC3079432

Electronic International Standard Serial Number (EISSN)

  • 1934-6069

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2008.05.002

Language

  • eng

Conference Location

  • United States