Is RNA interference involved in intrinsic antiviral immunity in mammals?

Journal Article (Journal Article;Review)

RNA interference constitutes a key component of the innate immune response to viral infection in both plants and invertebrate animals and has been postulated to have a similar protective function in mammals. This perspective reviews the available data addressing whether RNA interference forms part of the mammalian innate immune response and concludes that the popular hypothesis in favor of that possibility remains far from proven and may not be valid.

Full Text

Duke Authors

Cited Authors

  • Cullen, BR

Published Date

  • June 2006

Published In

Volume / Issue

  • 7 / 6

Start / End Page

  • 563 - 567

PubMed ID

  • 16715068

International Standard Serial Number (ISSN)

  • 1529-2908

Digital Object Identifier (DOI)

  • 10.1038/ni1352


  • eng

Conference Location

  • United States