Human papillomavirus genotype 31 does not express detectable microRNA levels during latent or productive virus replication.

Published

Journal Article

It has recently become clear that several pathogenic DNA viruses express virally encoded microRNAs in infected cells. In particular, numerous microRNAs have been identified in a range of human and animal herpesviruses, and individual microRNAs have also been identified in members of the polyoma- and adenovirus families. Although their functions remain largely unknown, it seems likely that these viral microRNAs play an important role in viral replication in vivo. Here we present an analysis of the microRNAs expressed in human cells during the latent and productive phases of the human papillomavirus genotype 31 (HPV31) replication cycle. Although over 500 cellular microRNAs were cloned and identified, not a single HPV31-specific microRNA was obtained. We therefore concluded that HPV31, and possibly human papillomaviruses in general, does not express viral microRNAs.

Full Text

Duke Authors

Cited Authors

  • Cai, X; Li, G; Laimins, LA; Cullen, BR

Published Date

  • November 2006

Published In

Volume / Issue

  • 80 / 21

Start / End Page

  • 10890 - 10893

PubMed ID

  • 17041229

Pubmed Central ID

  • 17041229

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/JVI.01175-06

Language

  • eng

Conference Location

  • United States