Recognition and cleavage of primary microRNA transcripts.


Journal Article (Review)

MicroRNAs (miRNAs) are approx 22-nucleotide (nt)-long, single-stranded, endogenous, noncoding RNAs that are widely expressed in multicellular organisms. This chapter describes methods that allow the overexpression of human miRNAs and also discusses how primary miRNAs (pri-miRNAs), the much longer precursors of mature miRNAs, are processed in human cells, as well as in vitro.

Full Text

Duke Authors

Cited Authors

  • Zeng, Y; Cullen, BR

Published Date

  • 2006

Published In

Volume / Issue

  • 342 /

Start / End Page

  • 49 - 56

PubMed ID

  • 16957366

Pubmed Central ID

  • 16957366

International Standard Serial Number (ISSN)

  • 1064-3745

Digital Object Identifier (DOI)

  • 10.1385/1-59745-123-1:49


  • eng

Conference Location

  • United States