The role of lipid rafts in the pathogenesis of bacterial infections.

Journal Article (Journal Article;Review)

Numerous pathogens have evolved mechanisms of co-opting normal host endocytic machinery as a means of invading host cells. While numerous pathogens have been known to enter cells via traditional clathrin-coated pit endocytosis, a growing number of viral and bacterial pathogens have been recognized to invade host cells via clustered lipid rafts. This review focuses on several bacterial pathogens that have evolved several different mechanisms of co-opting clustered lipid rafts to invade host cells. Although these bacteria have diverse clinical presentations and many differences in their pathogenesis, they each depend on the integrity of clustered lipid rafts for their intracellular survival. Bacterial invasion via clustered lipid rafts has been recognized as an important virulence factor for a growing number of bacterial pathogens in their battle against host defenses.

Full Text

Duke Authors

Cited Authors

  • Zaas, DW; Duncan, M; Rae Wright, J; Abraham, SN

Published Date

  • December 30, 2005

Published In

Volume / Issue

  • 1746 / 3

Start / End Page

  • 305 - 313

PubMed ID

  • 16289370

International Standard Serial Number (ISSN)

  • 0006-3002

Digital Object Identifier (DOI)

  • 10.1016/j.bbamcr.2005.10.003


  • eng

Conference Location

  • Netherlands