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TLR4-initiated and cAMP-mediated abrogation of bacterial invasion of the bladder.

Publication ,  Journal Article
Song, J; Bishop, BL; Li, G; Duncan, MJ; Abraham, SN
Published in: Cell Host Microbe
June 14, 2007

The remarkable resistance of the urinary tract to infection has been attributed to its physical properties and the innate immune responses triggered by pattern recognition receptors lining the tract. We report a distinct TLR4 mediated mechanism in bladder epithelial cells (BECs) that abrogates bacterial invasion, a necessary step for successful infection. Compared to controls, uropathogenic type 1 fimbriated Escherichia coli and Klebsiella pneumoniae invaded BECs of TLR4 mutant mice in 10-fold or greater numbers. TLR4 mediated suppression of bacterial invasion was linked to increased intracellular cAMP levels which negatively impacted Rac-1 mediated mobilization of the cytoskeleton. Artificially increasing intracellular cAMP levels in BECs of TLR4 mutant mice restored resistance to type 1 fimbriated bacterial invasion. This finding reveals a novel function for TLR4 and another facet of bladder innate defense.

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Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

June 14, 2007

Volume

1

Issue

4

Start / End Page

287 / 298

Location

United States

Related Subject Headings

  • Urothelium
  • Urinary Tract Infections
  • Urinary Bladder Diseases
  • Urinary Bladder
  • Toll-Like Receptor 4
  • Mice, Inbred C3H
  • Mice
  • Klebsiella pneumoniae
  • Immunology
  • Humans
 

Citation

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Song, J., Bishop, B. L., Li, G., Duncan, M. J., & Abraham, S. N. (2007). TLR4-initiated and cAMP-mediated abrogation of bacterial invasion of the bladder. Cell Host Microbe, 1(4), 287–298. https://doi.org/10.1016/j.chom.2007.05.007
Song, Jeongmin, Brian L. Bishop, Guojie Li, Matthew J. Duncan, and Soman N. Abraham. “TLR4-initiated and cAMP-mediated abrogation of bacterial invasion of the bladder.Cell Host Microbe 1, no. 4 (June 14, 2007): 287–98. https://doi.org/10.1016/j.chom.2007.05.007.
Song J, Bishop BL, Li G, Duncan MJ, Abraham SN. TLR4-initiated and cAMP-mediated abrogation of bacterial invasion of the bladder. Cell Host Microbe. 2007 Jun 14;1(4):287–98.
Song, Jeongmin, et al. “TLR4-initiated and cAMP-mediated abrogation of bacterial invasion of the bladder.Cell Host Microbe, vol. 1, no. 4, June 2007, pp. 287–98. Pubmed, doi:10.1016/j.chom.2007.05.007.
Song J, Bishop BL, Li G, Duncan MJ, Abraham SN. TLR4-initiated and cAMP-mediated abrogation of bacterial invasion of the bladder. Cell Host Microbe. 2007 Jun 14;1(4):287–298.
Journal cover image

Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

June 14, 2007

Volume

1

Issue

4

Start / End Page

287 / 298

Location

United States

Related Subject Headings

  • Urothelium
  • Urinary Tract Infections
  • Urinary Bladder Diseases
  • Urinary Bladder
  • Toll-Like Receptor 4
  • Mice, Inbred C3H
  • Mice
  • Klebsiella pneumoniae
  • Immunology
  • Humans