Harboring of particulate allergens within secretory compartments by mast cells following IgE/FcepsilonRI-lipid raft-mediated phagocytosis.

Journal Article

Although much is known regarding the exocytic responses of mast cells following allergen/IgE-mediated activation, little is currently known of the fate of the activating allergens, many of which are particles. We have found that IgE-bound particulate allergens were phagocytosed by activated mast cells in a lipid raft-dependent manner. The nascent allergen-containing phagosomes were found to transform into granule compartments by acquiring VAMP7 and serotonin and exhibited the capacity to empty their contents upon mast cell activation. When allergen-harboring mast cells were stimulated, the intracellular allergens were expelled intact and shown to activate adjacent mast cells. This capacity of mast cells to phagocytose and retain whole and antigenically intact allergens could potentially contribute to the course of inflammatory diseases such as asthma.

Full Text

Duke Authors

Cited Authors

  • Shin, J-S; Shelburne, CP; Jin, C; LeFurgey, EA; Abraham, SN

Published Date

  • November 1, 2006

Published In

Volume / Issue

  • 177 / 9

Start / End Page

  • 5791 - 5800

PubMed ID

  • 17056503

International Standard Serial Number (ISSN)

  • 0022-1767

Language

  • eng

Conference Location

  • United States