Bacterial outer membrane vesicles and the host-pathogen interaction.
Journal Article (Journal Article;Review)
Extracellular secretion of products is the major mechanism by which Gram-negative pathogens communicate with and intoxicate host cells. Vesicles released from the envelope of growing bacteria serve as secretory vehicles for proteins and lipids of Gram-negative bacteria. Vesicle production occurs in infected tissues and is influenced by environmental factors. Vesicles play roles in establishing a colonization niche, carrying and transmitting virulence factors into host cells, and modulating host defense and response. Vesicle-mediated toxin delivery is a potent virulence mechanism exhibited by diverse Gram-negative pathogens. The biochemical and functional properties of pathogen-derived vesicles reveal their potential to critically impact disease.
Full Text
Duke Authors
Cited Authors
- Kuehn, MJ; Kesty, NC
Published Date
- November 15, 2005
Published In
Volume / Issue
- 19 / 22
Start / End Page
- 2645 - 2655
PubMed ID
- 16291643
International Standard Serial Number (ISSN)
- 0890-9369
Digital Object Identifier (DOI)
- 10.1101/gad.1299905
Language
- eng
Conference Location
- United States