Bacterial outer membrane vesicles and the host-pathogen interaction.

Journal Article (Journal Article;Review)

Extracellular secretion of products is the major mechanism by which Gram-negative pathogens communicate with and intoxicate host cells. Vesicles released from the envelope of growing bacteria serve as secretory vehicles for proteins and lipids of Gram-negative bacteria. Vesicle production occurs in infected tissues and is influenced by environmental factors. Vesicles play roles in establishing a colonization niche, carrying and transmitting virulence factors into host cells, and modulating host defense and response. Vesicle-mediated toxin delivery is a potent virulence mechanism exhibited by diverse Gram-negative pathogens. The biochemical and functional properties of pathogen-derived vesicles reveal their potential to critically impact disease.

Full Text

Duke Authors

Cited Authors

  • Kuehn, MJ; Kesty, NC

Published Date

  • November 15, 2005

Published In

Volume / Issue

  • 19 / 22

Start / End Page

  • 2645 - 2655

PubMed ID

  • 16291643

International Standard Serial Number (ISSN)

  • 0890-9369

Digital Object Identifier (DOI)

  • 10.1101/gad.1299905


  • eng

Conference Location

  • United States