Multiple dosing of prostaglandin F2 alpha or epinephrine on cynomolgus monkey eyes. III. Histopathology.

Published

Journal Article

Prostaglandins (PGs), or their derivatives, are potent ocular hypotensive agents which may prove useful in glaucoma therapy. PGF2 alpha (250 micrograms in 50 microliter saline) or epinephrine 2% solution (50 microliter) was topically applied twice daily for 2 weeks to one eye of six cynomolgus monkeys for each agent. Contralateral control eyes received their respective vehicles. By light microscopy, there was no evidence of inflammation, corneal changes, retinal pathology (including cystoid macular edema), or other adverse effects. Likewise, by electron microscopy of the peripheral cornea, anterior chamber angle, iris base and ciliary body, no differences were noted between treated and control eyes. Therefore, multiple dosing with PGF2 alpha in subhuman primate eyes did not result in notable histopathological changes that would contraindicate a clinical trial in glaucoma patients.

Full Text

Duke Authors

Cited Authors

  • Camras, CB; Friedman, AH; Rodrigues, MM; Tripathi, BJ; Tripathi, RC; Podos, SM

Published Date

  • September 1988

Published In

Volume / Issue

  • 29 / 9

Start / End Page

  • 1428 - 1436

PubMed ID

  • 3166452

Pubmed Central ID

  • 3166452

International Standard Serial Number (ISSN)

  • 0146-0404

Language

  • eng

Conference Location

  • United States