Neurofibromatosis and neural crest neoplasms: primary acquired melanosis and malignant melanoma of the conjunctiva.

Journal Article (Journal Article;Review)

With an occurrence of approximately 1 in 3000 births, von Recklinghausen neurofibromatosis (NF) is one of the most common inherited human disorders. NF is considered a neurocristopathy, a disorder of neural crest derived cells. One of the complications of NF is the development of neural crest derived malignancies such as malignant schwannoma, pheochromocytoma, and malignant melanoma of the skin and choroid. The case history of a patient with NF and conjunctival malignant melanoma which developed in an eye with primary acquired melanosis is yet another example of a neural crest malignancy developing in a NF patient.

Full Text

Duke Authors

Cited Authors

  • To, KW; Rabinowitz, SM; Friedman, AH; Merker, C; Cavanaugh, CP

Published Date

  • March 1989

Published In

Volume / Issue

  • 33 / 5

Start / End Page

  • 373 - 379

PubMed ID

  • 2497540

International Standard Serial Number (ISSN)

  • 0039-6257

Digital Object Identifier (DOI)

  • 10.1016/0039-6257(89)90014-3


  • eng

Conference Location

  • United States