Gamma-butyrolactone sleep: A 24-hour rhythm paralleling normal sleep in the rat and CNS amine changes.

Journal Article (Journal Article)

The duration of sleep induced by a fixed dose of gamma-butyrolactone (GBL) (350 mg/kg, IP) FOllows the normal circadian sleep pattern of rats. GBL sleep duration is maximal at 1800 hr and minimal at 0600 hr. CNS amine changes are not extensive, but when normal sleep is anticipated, GBL treatment increases dopamine and serotonin levels and decreases norepinephrine levels.

Full Text

Duke Authors

Cited Authors

  • Speciale, SG; Friedman, AH

Published Date

  • 1975

Published In

Volume / Issue

  • 3 / 5

Start / End Page

  • 761 - 764

PubMed ID

  • 1208618

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/0091-3057(75)90103-3


  • eng

Conference Location

  • United States