Gamma-butyrolactone sleep: A 24-hour rhythm paralleling normal sleep in the rat and CNS amine changes.
Published
Journal Article
The duration of sleep induced by a fixed dose of gamma-butyrolactone (GBL) (350 mg/kg, IP) FOllows the normal circadian sleep pattern of rats. GBL sleep duration is maximal at 1800 hr and minimal at 0600 hr. CNS amine changes are not extensive, but when normal sleep is anticipated, GBL treatment increases dopamine and serotonin levels and decreases norepinephrine levels.
Full Text
Duke Authors
Cited Authors
- Speciale, SG; Friedman, AH
Published Date
- September 1, 1975
Published In
Volume / Issue
- 3 / 5
Start / End Page
- 761 - 764
PubMed ID
- 1208618
Pubmed Central ID
- 1208618
International Standard Serial Number (ISSN)
- 0091-3057
Digital Object Identifier (DOI)
- 10.1016/0091-3057(75)90103-3
Language
- eng
Conference Location
- United States